Coyote vs. Acme begins after Wile E. Coyote has faced decades of being blown to bits by bombs, demolished by dynamite, mangled by magnets, battered by boulders, trampled by trains, tricked by tunnels, sprung by springs, steamrolled by steamrollers, maligned by misfires, bedeviled by bungees, rattled by rockets, backstabbed by bat suits, rocked by rocket skates, upended by unicycles, quaked by quake pills, rubberized by rogue bands, and hurled headlong off every cliff in the Southwest. The antihero has finally decided to fight back. Teaming up with billboard accident lawyer Kevin Avery (Will Forte), he takes on slick corporate counsel Buddy Crane (John Cena) and ACME Inc., the profit-obsessed conglomerate behind every one of the Coyote’s chaotic catastrophes, having failed him one too many times in his dogged pursuit of the Roadrunner.

Directed by Dave Green, Coyote vs. Acme stars John Cena, Lana Condor, Will Forte, P.J. Byrne, Zoe Buchansky, Nancy Linehan Charles, Bennie Taylor, Hayes Hargrove, Tucker Hawkey, Jeff Bergman, Eric Bauza, Phuong Kubacki, Luis Guzmán, Jim Cummings, Laura-Love Tode and Carl Savering.

Coyote vs. Acme was the third film Warner Bros. Discovery CEO David Zaslav shelved during his tenure at the studio, for a tax write-off. The other two projects were Batgirl and Scoob!: Holiday Haunt, which were shelved near the end of post-production in August 2022. Unlike the former two, however, Coyote vs. Acme’s rights were sold to alternative distributor Ketchup Entertainment.